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1996-03-04
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Document 0708
DOCN M9640708
TI Intestinal absorptive capacity, intestinal permeability and jejunal
histology in HIV and their relation to diarrhoea.
DT 9604
AU Keating J; Bjarnason I; Somasundaram S; Macpherson A; Francis N; Price
AB; Sharpstone D; Smithson J; Menzies IS; Gazzard BG; Department of
Medicine, Chelsea and Westminster Hospital, London.
SO Gut. 1995 Nov;37(5):623-9. Unique Identifier : AIDSLINE MED/96148575
AB Intestinal function is poorly defined in patients with HIV infection.
Absorptive capacity and intestinal permeability were assessed using
3-O-methyl-D-glucose, D-xylose, L-rhamnose, and lactulose in 88 HIV
infected patients and the findings were correlated with the degree of
immunosuppression (CD4 counts), diarrhoea, wasting, intestinal pathogen
status, and histomorphometric analysis of jejunal biopsy samples.
Malabsorption of 3-O-methyl-D-glucose and D-xylose was prevalent in all
groups of patients with AIDS but not in asymptomatic, well patients with
HIV. Malabsorption correlated significantly (r = 0.34-0.56, p < 0.005)
with the degree of immune suppression and with body mass index.
Increased intestinal permeability was found in all subgroups of
patients. The changes in absorption-permeability were of comparable
severity to those found in patients with untreated coeliac disease.
Jejunal histology, however, showed only mild changes in the villus
height/crypt depth ratio as compared with subtotal villus atrophy in
coeliac disease. Malabsorption and increased intestinal permeability are
common in AIDS patients. Malabsorption, which has nutritional
implications, relates more to immune suppression than jejunal
morphological changes.
DE Adult Body Mass Index Celiac Disease/PATHOLOGY/PHYSIOPATHOLOGY
Comparative Study CD4 Lymphocyte Count Diarrhea/*ETIOLOGY/PATHOLOGY
Female Human HIV Infections/COMPLICATIONS/PATHOLOGY/*PHYSIOPATHOLOGY
*Intestinal Absorption Jejunum/PATHOLOGY/PHYSIOPATHOLOGY Male Middle
Age Support, Non-U.S. Gov't JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).